Delhi gang-rape victim dies in hospital in Singapore
The attack earlier this month triggered violent public protests in India that left one police officer dead.
Indian Prime Minister Manmohan Singh said he was "very saddened" and promised to channel "emotions and energies" into a course of action.
Six men have been arrested and two police officers have been suspended following the 16 December attack.
A statement from the hospital said the woman "passed away peacefully" early on Saturday with her family by her side.
"The patient had remained in an extremely critical condition since admission to Mount Elizabeth Hospital," hospital chief executive Kelvin Loh said.
"She had suffered from severe organ failure following serious injuries to her body and brain. She was courageous in fighting for her life for so long against the odds but the trauma to her body was too severe for her to overcome.
"We are humbled by the privilege of being tasked to care for her in her final struggle," Mr Loh said.